Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality

The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain incompletely understood. As disease pathogenesis often cannot be attributed to visible cerebrospinal fluid (CSF) drainage obstructions, we here aimed elucidate whether elevated CSF osmolality following subarachnoid hemorrhage (SAH) could potentiate formation ventricular fluid, and thereby contribute pathological accumulation observed in PHH. was determined 32 patients with acute SAH after external (EVD) placement again upon EVD removal compared from 14 healthy control subjects undergoing vascular clipping an unruptured aneurism. However, found no evidence or electrolyte concentration when that subjects. We detected difference content successful weaning versus those were shunted due Taken together, does not appear underlie PHH SAH. this patient group must thus instead other alterations associated abnormal presence blood within compartments